Once-daily dose1
No restrictions for patients ≥3 months of age in PFIC and ≥12 months of age in ALGS
Taken with a morning meal1
No need to delay feeding or mealtimes after dosing— take Bylvay at the regular feeding schedule
Bylvay can be taken 3 ways1
Swallowed whole
Mixed with food
Mixed with liquids
- Capsules can be swallowed whole—or can be opened; pellets can be mixed with soft food, or
add 1 teaspoon (5 mL) of an age-appropriate liquid (for example, breast milk, infant formula, or water)
Bylvay recommended doses1
Recommended
starting dose
for PFIC
40
mcg/kg/day
If there is no improvement in pruritus after 3
months, the dosage may be increased in 40 mcg/kg
increments up to 120 mcg/kg once daily, not to
exceed a daily dosage of 6 mg/day.
If there is no improvement in pruritus after 3
months, the dosage may be increased in 40
mcg/kg increments up to 120 mcg/kg once
daily, not to exceed a daily dosage of 6 mg/
day.
Recommended
starting dose
for ALGS
120
mcg/kg/day
Dose reduction to 40 mcg/kg/day may be considered if tolerability issues occur in the absence of other causes. Once tolerability issues stabilize, increase to 120 mcg/kg/day.
For a helpful dose-per-weight guide and complete instructions on dosage and administration, see
the full Prescribing Information.
Oral Pellets are intended for use by patients weighing less than 19.5 kilograms.
Capsules are intended for use by patients weighing 19.5 kilograms or more.
Dosing Guide
Learn more about Bylvay dosing, titration, and more by downloading the
Dosing Guide
ALGS=Alagille syndrome; PFIC=progressive familial intrahepatic cholestasis.
Reference:
- Bylvay Prescribing Information. Boston, MA: Albireo Pharma, Inc.; 2023.